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Cisco Secure Email Threat Defense

Complete Email Security Protection, Simplified

Modernize your email security into a singular, continuously evolving, advanced platform — driven by cloud-scale AI detections. Robust security that protects every mailbox without the operational overhead of traditional appliances.

A Truly Cloud-Scale Architecture for Robust Email Security

Expansive email security that protects your employees and organization while empowering your security response. Cisco Secure Email Threat Defense harnesses cloud-scale AI to stop threats before they reach the mailbox — with a unified platform that manages both inline gateway and API-based deployments from a single console.

  • Cloud-scale AI eliminates traditional appliance-based limitations
  • Pre-delivery threat blocking before messages reach the mailbox
  • Unified inline gateway and API deployment in one console
  • FedRAMP authorized for government and regulated industry customers

Four Core Capabilities That Set Secure Email Apart

Each capability addresses a distinct operational challenge — together they form a complete email security platform that scales with your organization.

Cloud-Scale, AI-Driven Gateway Capabilities

Harness cloud-scale AI in a unified platform that eliminates traditional appliance-based limitations and reduces overhead. Advanced machine learning models analyze message content, sender behavior, and threat context at a scale no on-premises appliance can match.

Comprehensive Pre-Delivery Threat Protection

Proactively stop email threats before they reach the mailbox. Every inbound message is inspected for malicious URLs, attachments, sender reputation anomalies, and social engineering tactics — helping to ensure compliance and a safer, protected environment.

Unified and Flexible Platform

Gain flexible threat protection through a cohesive interface that unifies inline gateway and API-based deployment modes into a single console. Manage pre-delivery threat prevention and post-delivery remediation from one place, reducing operational complexity.

Simplified Management and Robust Security

Streamline maintenance and accelerate your email security journey with cloud-scale AI and seamless platform integration. Reduce the overhead of managing separate systems while getting stronger, more consistent protection across your entire email environment.

Market Leadership

Top Rankings Across Four Categories in KuppingerCole Leadership Compass

Secure Email Threat Defense has once again set itself apart from the competition in the KuppingerCole Leadership Compass for Email Security, earning top rankings in four different categories. Independent analysts consistently recognize the platform for its AI-driven detection accuracy, cloud-native architecture, and rapid innovation pace.

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KuppingerCole Leadership Compass report displayed on notebook
Cisco Secure Email government compliance and FedRAMP authorization

Government & Compliance

Trusted, Proven, and FedRAMP Authorized

Email Threat Defense achieves a critical milestone that underscores Cisco's commitment to delivering the highest standards of security and compliance. FedRAMP authorization enables government agencies and regulated industry customers to deploy with confidence, knowing the platform meets rigorous federal security requirements.

  • FedRAMP authorized — meets U.S. federal security requirements
  • Supports HIPAA, FISMA, and regulated industry compliance needs
  • Available for federal, state, and local government agencies
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Independent Testing

SE Labs AAA Rating for Email Threat Detection

Sophisticated AI detectors in Cisco Secure Email Threat Defense provide the highest level of email threat protection, according to SE Labs research. This AAA rating confirms that Secure Email Threat Defense delivers industry-leading effectiveness at detecting and blocking email-borne attacks under real-world conditions.

  • AAA rating — the highest score from SE Labs
  • Tested against sophisticated phishing, BEC, and malware campaigns
  • AI detectors validated for enterprise-scale accuracy
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Screenshot of Secure Email Threat Defense UI showing advanced AI threat detection

Cisco AI

Advanced Threat Detection Powered by Strategic AI

See how Secure Email Threat Defense uses AI to identify the intent and risk behind every email-based threat. Cisco's strategic use of AI empowers the platform to understand the context of each message — not just its content — so it can detect sophisticated attacks that rule-based systems and legacy gateways miss.

  • Identifies threat intent, not just malicious indicators
  • Relationship graph analysis for non-content contextual detection
  • Continuously evolving AI models trained on global threat telemetry
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Screenshot of Secure Email Threat Defense UI

Stronger Together with the Cisco Security Portfolio

Secure Email Threat Defense integrates with the broader Cisco security ecosystem to provide layered protection across email, endpoints, identity, and network — closing gaps that standalone email security cannot address.

Cisco Breach Protection Suite

Empower your security teams to respond to threats at speed with innovative XDR and global telemetry. Correlate email-borne threats with endpoint, network, and cloud activity for complete attack visibility and faster response.

Cisco User Protection Suite

Enable seamless and secure access for trusted users to protect against identity-based attacks. Combine email threat defense with identity and access controls for comprehensive user-centric security.

Cisco Secure Endpoint

Stop threats before they cause compromise with powerful detection and response capabilities. Together, Secure Email and Secure Endpoint cover the two most common attack entry points in any organization.

Cisco Security Step-Up promotion

Three Vital Protections in a Single Step

You do not have to trade security for productivity. The Cisco Security Step-Up promotion deploys three powerful lines of defense that are simple, secure, and resilient for your business. Defend every critical attack vector — email, web traffic, and user credentials — in one easy step.

Get Step-Up Pricing

Straightforward Per-User Licensing

Pricing is on a per-user basis, applying to each knowledge worker in your organization. Flexible terms and bundling options make it easy to scale protection as your organization grows.

Per-User Pricing

Simple per-user licensing that scales with your workforce. Each license covers a single knowledge worker across all deployment modes — inline gateway and API.

Flexible Terms

Choose 1-, 3-, or 5-year subscription terms with significant savings on multiyear options. No extra charge for scheduled billing — monthly, quarterly, yearly, or full payment.

Bundling & Financing

Include subscriptions in larger Cisco buying programs — Security Bundles or Enterprise Agreements. Cisco Capital financing options are also available.

24/7 TAC Support

Every subscription includes Cisco Technical Assistance Center support around the clock, plus customer success onboarding assistance to accelerate deployment.

Featured Research and Resources

Independent research and technical documentation to help you evaluate Cisco Secure Email Threat Defense.

Email Threat Defense Achieves SE Labs AAA Rating

Sophisticated AI detectors in Cisco Secure Email Threat Defense provide the highest level of email threat protection, according to SE Labs research.

Frost Radar™: Cisco Is a Growth Leader

Frost & Sullivan recognizes Secure Email Threat Defense for its incredible market growth, advances in AI, and global expansion across enterprise and government sectors.

Relationship Graphs Mitigate Email Threats

See how Email Threat Defense leverages non-content contextual information from relationship graphs to provide crucial context that content analysis alone cannot detect.

Innovations in Email Security

Email Threat Defense unifies multiple deployment modes into a single, flexible solution offering pre-delivery threat prevention and post-delivery remediation via APIs in one streamlined console.

Related Cisco Security Solutions

Extend your email security posture with solutions that integrate with Cisco Secure Email Threat Defense.

Cisco XDR

Extend email threat intelligence into unified cross-domain detection and response. Cisco XDR correlates email-borne threats with endpoint, network, and cloud activity for faster investigation and remediation.

Cisco Secure Endpoint

Stop threats that bypass email defenses with advanced endpoint protection, EDR, and threat hunting. Together, you cover the two most targeted attack surfaces in any organization.

Cisco Umbrella

Add DNS-layer security to block malicious domains at the network edge. Umbrella and Secure Email together provide layered protection covering both email threats and web-based attacks.

Cisco Duo

Protect user identities with phishing-resistant MFA. Even when phishing emails slip through any system, Duo ensures stolen credentials cannot be used to compromise accounts.

Protect Your Organization’s Email Today

Our Cisco-certified team can help you evaluate, license, and deploy Secure Email Threat Defense. Discover how the advanced threat detection capabilities provide effective and comprehensive protection for your Microsoft 365 environment — with a free trial to prove it.

  • Cloud-scale AI detection for phishing, BEC, and ransomware
  • FedRAMP authorized for government and regulated industry deployments
  • Flexible per-user licensing with 1-, 3-, and 5-year terms
  • Response from a certified Cisco specialist within one business day